Statin Use in Patients With Acute Pancreatitis and Symptomatic Gallstone Disease
Pulkkinen, J; Kastarinen, H; Kiviniemi, V; Jyrkkä, J; Juvonen, P; Räty, S; Paajanen, H (2014)
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Pulkkinen, J
Kastarinen, H
Kiviniemi, V
Jyrkkä, J
Juvonen, P
Räty, S
Paajanen, H
2014
Pancreas
Tiivistelmä
Objective: The long-term use of statins may be associated with a decreased
risk for gallstones and biliary-induced acute pancreatitis (AP).
Our aim was to study the relationship of statin use and outcome of AP.
Methods: We investigated the records of 461 consecutive patients with
AP and 1140 patients with symptomatic gallstones during 2008 to 2010.
The use of lipid-lowering drugs, patient’s characteristics, and outcome of
patients were recorded. All known risk factors for AP and particularly
statin use in idiopathic AP were analyzed.
Results: Statin use was comparable between the patients with AP
(22%) and patients with cholelithiasis (24%). The frequencies of surgical
treatment, duration of hospital stay, or mortality were not different
between the statin users compared with the nonusers. Idiopathic AP was
more often associated with the use of statins than alcohol- or gallstoneinduced
AP (44% vs 30% vs 13%, P G 0.002). The etiology of AP was
alcohol in 56% of the patients, gallstones in 28% of the patients, and
unknown (idiopathic) or miscellaneous in 16% of the patients.
Conclusions: No beneficial effect of statins was observed in mortality
or other outcome parameters of patients with AP. Statin use was more
frequent in patients with idiopathic AP than in patients with biliary- or
alcohol-induced AP.
risk for gallstones and biliary-induced acute pancreatitis (AP).
Our aim was to study the relationship of statin use and outcome of AP.
Methods: We investigated the records of 461 consecutive patients with
AP and 1140 patients with symptomatic gallstones during 2008 to 2010.
The use of lipid-lowering drugs, patient’s characteristics, and outcome of
patients were recorded. All known risk factors for AP and particularly
statin use in idiopathic AP were analyzed.
Results: Statin use was comparable between the patients with AP
(22%) and patients with cholelithiasis (24%). The frequencies of surgical
treatment, duration of hospital stay, or mortality were not different
between the statin users compared with the nonusers. Idiopathic AP was
more often associated with the use of statins than alcohol- or gallstoneinduced
AP (44% vs 30% vs 13%, P G 0.002). The etiology of AP was
alcohol in 56% of the patients, gallstones in 28% of the patients, and
unknown (idiopathic) or miscellaneous in 16% of the patients.
Conclusions: No beneficial effect of statins was observed in mortality
or other outcome parameters of patients with AP. Statin use was more
frequent in patients with idiopathic AP than in patients with biliary- or
alcohol-induced AP.
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